《生命科学》 2010, 22(2): 115-118

A型流感病毒NS1蛋白结构研究进展

郭莹莹， 王靖飞^*

(中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室，哈尔滨 150001)

摘　要：摘  要：近年来A型流感严重威胁着人类和畜禽的健康，随着研究的深入，人们已经发现A型流感病毒的NS1蛋白对病毒毒力有重要影响，是一个多功能毒力因子、宿主细胞抗病毒免疫抑制子。根据其功能的不同分为效应区和RNA结合域。目前NS1蛋白结构已经解析，使人们可以直观的认识其各个功能位点的作用机制。该文综述了NS1蛋白的结构特征、已知的功能位点及其功能，为在结构水平上研究NS1蛋白的功能提供参考。
关键词：A型流感病毒; 非结构蛋白; 结构; 功能

Progresses in structure studies of influenza A virus NS1 protein

GUO Ying-ying， WANG Jing-fei^*

(State Key Laboratory of Biotechnology， Harbin Veterinary Research Institute， Chinese Academy of Agricultural Sciences， Harbin 150001，China)

Abstract: Abstract: Nonstructural protein 1(NS1)have been reported as one of the major virulence factors of Influenza A virus. The protein is a small， dimeric， multi-functional protein which takes part in both protein-protein and protein-RNA interactions， and has a crucial role in the ability of the virus to evade the antiviral response of the infected cells. According to its multiple functions， NS1A protein is made up of two domains: an N-terminal RNA-binding domain (RBD) (residues 1-73) and a C-terminal effector domain (ED) (residues 84-230/237). The structures of the two domains have been crystallized. In this review， we described the current understanding of NS1A structure and function as well as the relationship between them.
Key words: Influenza A virus; nonstructural protein; structure; function