《生命科学》 2010, 22(1): 84-88

HIV-1 Tat蛋白神经毒作用的研究进展

滕竞飞¹，高霄飞^2*

(1第二军医大学临床医学八年制，上海 200433；2第二军医大学神经生物学教研室，上海 200433)

摘　要：摘　要：HIV-1感染者常并发神经系统损伤，患者主要表现为运动功能障碍，认知和行为受损等。研究表明，HIV-1多种蛋白参与上述病理过程，其中Tat蛋白发挥了极为重要的作用。外周Tat蛋白可透过血脑屏障进入脑组织，与脑内感染细胞分泌或释放至胞外的Tat共同作用于NMDAR、mGluR1、多巴胺转运蛋白等，损伤神经系统。该文主要对Tat蛋白的神经毒作用作一综述。
关键词：HIV-1 Tat；血脑屏障；神经毒

Progress in study on neurotoxicity of HIV-1 Tat

TENG Jing-fei¹， GAO Xiao-fei^2*

(1 Eight-year-system Clinical Medicine， Second Military Medical University， Shanghai 200433， China;2 Department of Neurobiology， Second Military Medical University， Shanghai 200433， China)

Abstract: Abstract: Infection with HIV-1 is always associated with dysfunctions of central nervous system(CNS)， the patients are characterized by motor dysfunctions， impaired cognitions and behaviors. Relative researches indicated that， various HIV-1 proteins are responsible for the pathogenesis， among which， Tat is of vital importance. Peripheral Tat， which can cross the blood-brain barrier and infiltrate the brain tissues， as well as that secreted or released from HIV-1-infected cells， can interact with NMDAR， mGluR1， dopamine transporter， etc. and thus cause damages to central nervous system (CNS). The neurotoxicity effects of HIV-1 Tat were reviewed here.
Key words: HIV-1 Tat; blood-brain barrier; neurotoxicity