《生命科学》 2010, 22(1): 69-73

HER-2/neu基因高表达及靶向治疗

陈宇萍

(海军总医院基础医学研究中心，北京100048)

摘　要：摘　要：HER-2/neu癌基因在许多肿瘤，如乳腺癌、卵巢癌、非小细胞肺癌等肿瘤中高表达，在肿瘤的发生与发展中起重要作用，与肿瘤的转化、转移、复发、预后差、患者生存期缩短有关。HER-2/neu在乳腺癌过度表达率约为20%~30%，编码蛋白P185HER2属生长因子受体家族，抗P185HER2单克隆抗体(Herceptin)作为靶向药物已临床应用治疗HER2/neu高表达乳腺癌。
关键词：HER-2/neu基因；P185HER2； 靶向治疗

Over-expression of HER-2/neu and targeted therapy

CHEN Yu-ping

(Center of Basic Medical Science， Navy General Hospital of PLA， Beijing 100048， China)

Abstract: Abstract: HER-2/neu oncogene is overexpressed in many kinds of tumors like breast cancer， ovarian cancer， nonsmall-cell lung cancer(NSCLC). Overexpression of HER-2/neu has significant effect on tumor occuring and development， it is associated with tumor inversion， metastasis， recuring， poorer prognosis and patient{$39}s shortening of life. HER-2/neu is overexpressed in approximately 20%~30% patients with breast cancer. The coding protein P185HER2 of HER-2/neu is a member of the human epidermal growth factor receptor family. Monoclonal antibody of P185HER2(Herceptin) is clinically used as a targeted drug for HER-2/neu overexpressed breast cancer.
Key words: HER-2/neu; P185HER2; targeted therapy