《生命科学》 2009, 21(4): 560-565

Let-7家族对细胞“干性”的调控

王斯瑶1，安　靓2*

1 南方医科大学基础医学院基础医学系，广州 510515；2 南方医科大学肿瘤研究所，广州 510515

摘　要：摘　要：Let-7是目前研究最为广泛的microRNA家族之一。通过转录后调控机制，let-7可以特异性结合到信使RNA(mRNA)上，从而降解靶基因mRNA或抑制其翻译。研究表明，let-7家族在干细胞与肿瘤干细胞中参与多种调控机制，在维持干细胞特性(stemness)，即高增殖、低分化和自我更新能力的过程中起到重要调控作用。本文将从干细胞与肿瘤干细胞两个方面，综述let-7与细胞“干性”间存在的联系和调控机制。
关键词：let-7；microRNA；干细胞；肿瘤干细胞

Regulating function of let-7 family on cell stemness

WANG Si-yao1， AN Jing2*

1 Basic Medicine， School of Basic Medical Science， Southern Medical University， Guangzhou 510515， China; 2 Cancer Institute of Southern Medical University， Guangzhou 510515， China

Abstract: Abstract: Originally discovery indicates a class of miRNA， let-7， which binds to target messenger RNAs (mRNA) through a post-transcription regulation and induces either translation repression or mRNA degradation， plays a regulatory role in the stem cells /cancer stem cells self renewal， development， differentiation， metastasis and apoptosis. Based on these findings about let-7抯 function and its regulatory processes， this review will summarizes these processes and the potential role in the stem cell and cancer stem cell. A more complete understand of its function on stemness will thus find new solution to the research， the diagnose and therapy of human cancer.
Key words: let-7; microRNA; stem cell; cancer stem cells