《生命科学》 2009, 21(4): 494-498

卵泡颗粒细胞凋亡相关蛋白的研究进展

王昭晖，张耀君，师　红，文瑞丽，吴民耀*

陕西师范大学生命科学学院，药用资源与天然药物化学教育部重点实验室，西北濒危药材资源开发国家工程实验室，西安 710062

摘　要：

摘　要：哺乳动物的卵巢中存在大量卵泡。大多数卵泡在发育过程中发生闭锁而消失，只有少数可以发育到成熟而排卵。卵泡是由卵母细胞与其周围的颗粒细胞构成的。卵泡颗粒细胞的凋亡是卵泡闭锁的主要原因。颗粒细胞凋亡相关蛋白通过参与凋亡通路及凋亡信号转导调节凋亡。本文就哺乳动物卵泡颗粒细胞凋亡相关蛋白的研究进展进行综述。
关键词：卵泡; 凋亡蛋白；颗粒细胞凋亡

Recent research on apoptosis-associated proteins of follicular granulosa cells

WANG Zhao-hui， ZHANG Yao-jun， SHI Hong， WEN Rui-li， WU Min-yao*

Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry， National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China， College of Life Science， Shaanxi Norma

Abstract:
Abstract: There are a large amount of follicles in mammalian ovary. Most of the follicles undergo atresia during the process of follicular development and then disappear， only a few of them mature and ovulate. Ovarian follicles are consisted with oocytes and the granulosa cells around them. The apoptosis of granulosa cells is the main reason for follicle atresia. Apoptosis-associated proteins regulate apoptosis through taking part in the apoptosis pathway and the signal transduction in apoptosis. This review focuses the recent researches on the proteins which regulate the process of the apoptosis of follicular granulose cells.
Key  words: follicle; apoptosis protein; granulosa cells apoptosis