《生命科学》 2009, 21(3): 430-433

IRAK-M在TLRs信号转导中负性调节作用的研究进展

郑佳佳1，2，万敬员1*

（1重庆医科大学重庆市生物化学与分子药理学重点实验室；2重庆医科大学2005级儿科七年制，重庆 400016）

摘　要：摘　要：白细胞介素1受体相关激酶(interleukin-1 receptor-associatd kinase， IRAK)家族被认为是TLR/IL-1R信号通路中重要的信号分子。迄今为止，已发现4个IRAK家族成员，其中IRAK-1和IRAK-4有激酶活性，IRAK-2和IRAK-M无激酶活性。最近的研究发现IRAK-M参与负性调控TLR信号通路和具有天然免疫的作用。本文就IRAK-M的结构特点及在TLR信号转导的分子机制和免疫耐受中的作用进行综述。
关键词：白细胞介素1受体相关激酶-M；Toll样受体；负性调节

The progress in research of effects of IRAK-M on negative regulating TLRs signaling pathway

ZHENG Jia-jia1，2， WAN Jing-yuan1*

(1 Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology， Chongqing Medical University; 2 2005-7 years majors of clinic medicine， Chongqing Medical University， Chongqing 400016， China)

Abstract: Abstract: The interleukin-1 receptor-associated kinase (IRAK) family is thought to be a type of key signal molecules in TLR/IL-1R-mediated signal pathway. So far， Four IRAK family members have been found， which consists of two active kinases， IRAK and IRAK-4， and two inactive kinases， IRAK-2 and IRAK-M. In recent studies， IRAK-M has been considered to involve in negatively regulating of TLR signaling and innate immune homeostasis. This review will discuss the progress in the structure， function and molecular mechanism of  TLR signaling regulation and immune tolerance of IRAK-M.
Key words: IRAK-M; TLRs; negative regulation