《生命科学》 2009, 21(3): 353-356

细胞重编程的分子机制

陈涛涛1，康九红2*

(1中国科学院上海生命科学研究院生物化学与细胞生物学研究所，上海200031；2同济大学生命科学与技术学院，上海 200092)

摘　要：摘　要：细胞重编程，尤其是诱导多能性干细胞的出现，给再生医学带来极大的希望。近年来，这方面的研究吸引了众多科学家的参与，也取得了非常丰富的成果。本文主要从转录因子、表观遗传和信号转导等角度，介绍了细胞重编程分子机制研究方面的进展和未来的方向。
关键词：细胞重编程；诱导多能性干细胞；转录因子；表观遗传；信号转导

Molecular mechanisms of cell reprogramming

Chen Tao-tao1， Kang Jiu-hong2*

(1Laboratory of Molecular Cell Biology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China; 2School of Life Science and Technology， Tongji University， Shanghai

Abstract: Abstract: Cell reprogramming， especially the generation of induced pluripotent stem cells (iPSC) has opened a new horizon in the treatment of degenerative illnesses. Studies on the generation and mechanisms of iPSC have been the hot-spot and breathtaking progresses， which have been made since the first report on the iPSC generation. In the present paper we review the role and molecular mechanism of transcription factors， epigenetic regulation and cell signaling in cell reprogramming.
Key words: cell reprogramming; induced pluripotent stem cell; transcription factor; epigenetics; cell signaling