《生命科学》 2009, 21(4): 556-559

上皮间质转化在肿瘤侵袭转移中的研究进展

张慧君1，朱　军1，刘鸿程1，王和勇1，2*，陈晓峰1*

（1同济大学附属上海市肺科医院，上海 200433；2同济大学医学院肿瘤研究所，上海 200433

摘　要：摘　要：上皮-间质转化(epithelial-mesenchymal transitions， EMT)是上皮细胞向间质细胞转化的现象，不仅参与胚胎发育和正常生理，还参与许多病理过程。同样EMT也参与肿瘤的发生与发展，尤其在促进肿瘤侵袭转移中发挥着重要作用。研究表明，肿瘤细胞借助EMT方式增强肿瘤细胞迁移和运动能力，促进肿瘤的侵袭与转移。在肿瘤侵袭转移历程中，关于EMT发生的分子调控机制研究已取得了良好的进展，但其详细机制仍然不是十分清楚。本文主要介绍生长因子、转录因子、miRNAs、甲基化及其他调控因子在肿瘤EMT中的调控功能，进一步综述EMT在肿瘤侵袭转移中的作用。
关键词：上皮-间质转化；肿瘤；肿瘤侵袭转移

The research progress of epithelial-mesenchymal transition in tumor invasion and metastasis

ZHANG Hui-jun1， ZHU Jun1， LIU Hong-cheng1， WANG He-yong1，2*， CHEN Xiao-feng1*

1Shanghai Pulmonary Hospital， Tongji University， Shanghai 200433， China; 2Department of Oncology， Shanghai Pulmonary Hospital， Medical School of Tongji University， Shanghai 200433， China

Abstract: Abstract: Epithelial-mesenchymal transitions(EMT)where cells undergo a switch from epithelial phenotype to mesenchymal phenotype exists not only in the embryo development and physiological processes， but also participates in many pathological processes. EMT plays an  important role in the development of tumor， especially in the progress of tumor invasion and metastasis. It has been demonstrated that turning tumor epithelial cells into mesenchymal cells made cells gain more ability of migration and locomotion and enhanced the ability of tumor invasion and metastasis. In the progress of tumor invasion and metastasis， the molecular mechanism of EMT is still unknown， but many relevent researches of EMT have had a good progress. This review mainly involves many molecular regulatory functions of growth factors， transcription factors， miRNAs， DNA methylation and other control factors in EMT and the role of EMT in the progress of tumor invasion and metastasis.
Key words: EMT; tumor; tumor invasion and metastasis