《生命科学》 2009, 21(3): 425-429

核受体与脂质代谢

董　琳， 吴　涛， 杨志秋， 傅正伟*

(浙江工业大学生物与环境工程学院，杭州 310014)

摘　要：摘　要：核受体是配体活化的转录因子，能调控大量的靶基因。近年来核受体调节脂质代谢的研究已成为国内外研究的热点。由于核受体在调节脂质代谢、糖代谢以及炎症反应方面发挥重要作用，它们是治疗心血管疾病理想的靶标。本文简要地介绍了核受体在调节脂质代谢方面的研究进展。
关键词：胆汁酸；胆固醇；核受体；脂肪酸；动脉粥样硬化

Nuclear receptors and lipid metabolism

DONG Lin， WU Tao， YANG Zhi-qiu， FU Zheng-wei*

(College of Biological and Enviromental Engineering， Zhejiang University of Technology， Hangzhou 310014， China)

Abstract: Abstract: Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. Recently， studies focusing on the regulation of lipid metabolism by nuclear receptors have gained increasing attention home and abroad. As NRs play major roles in the regulation of lipid metabolism， glucose homeostasis， and inflammatory processes， they are considered as ideal targets for the treatment of cardiovascular diseases. This paper briefly reviews the researches on the regulation of lipid metabolism by nuclear receptors.
Key words: bile acid; cholesterol; nuclear receptors; fatty acid; atherosclerosis