《生命科学》 2009, 21(3): 418-424

新型microRNA—miR-34在肿瘤中的研究进展

王苟思义， 袁贤瑞*， 蒋星军

(中南大学湘雅医院神经外科，长沙 410008)

摘　要：摘　要：miR-34是一类保守的、非编码miRNA。人类miR-34包括miR-34a、miR-34b和miR-34c等，在多种肿瘤中都呈现非正常表达。miR-34通过被p53激活，抑制E2F3、Bcl-2、c-myc、CDK4、CDK6、Cyclin D1以及Cyclin E2的表达，使肿瘤细胞停滞在G1期，抑制肿瘤细胞的生长，诱导肿瘤细胞凋亡，并通过E2F3、SIRT1与p53形成正反馈环路，不断增强其自身和p53的作用。本文就miR-34的研究进展进行综述。
关键词：miR-34; p53; Bcl-2; E2F; Cyclin/CDK; SIRT1

The role of a novel microRNA family， miR-34s， in tumor

WANG Gou-si-yi， YUAN Xian-rui*， JIANG Xing-jun

(Department of Neurosurgery， Xiangya Hospital， Central South University， Changsha 410008， China)

Abstract: Abstract: MiR-34 family is a series of conservative and non-coding miRNAs. Human miR-34s include miR-34a， miR-34b and miR-34c， which express abnormally in various types of tumors. Activated by p53 gene， miR-34s suppress the expression of E2F3， Bcl-2， c-myc， CDK4， CDK6， Cyclin D1 and Cyclin E2. Such suppression results  in apoptosis and G1 cell cycle arrest of tumor cell. E2F3 and SIRT1 make a positive feedback loop between miR-34 and p53 occur. As a result， the feedback loop enhances and amplifies the function of p53 and miR-34s themselves.
Key words: miR-34; p53; Bcl-2; E2F; Cyclin/CDK; SIRT1