《生命科学》 2009, 21(3): 452-455

肿瘤生物治疗的新方法——减毒鼠伤寒沙门菌的应用

冉　茜，胡昌华*

(西南大学药学院，重庆 400715)

摘　要：

New approach of biotherapy for cancer朼pplication of attenuated Salmonella typhimurium

RAN Qian， HU Chang-hua*

(School of Pharmaceutical Science， Southwest University， Chongqing 400715， China)

Abstract: Abstract: Considering its tumor targeting， replication in tumor tissues and anti-tumor effects， attenuated Salmonella typhimurium has offered a new approach to tumor therapy. As a anti-tumor bacteria vector ， S. typhimurium made gene express specifically in tumor tissue which showed the optimistic curative effect. Recent research revealed that the cure rate of the breast and prostate cancer in athymic mouse were up to 40% or 50% when a mutant of S. typhimurium A1-R was treated alone. It also showed a satisfactory treatment effect in the mouse tumor metastasis model. S. typhimurium has been the hot pot in the tumor research in recent years for its attractive prospects in tumor therapy. This article mainly reviewed the recent progress of S. typhimurium in tumor biotherapy.
Key words: attenuated Salmonella typhimurium; live vector vaccine; gene therapy; bacteria therapy