《生命科学》 2009, 21(1): 116-121

Hedgehog信号通路在肿瘤中作用的研究进展

李晓伟，刘炳亚*

上海交通大学医学院附属瑞金医院外科，上海消化外科研究所，上海200025

摘　要：摘　要：癌的发生是一个多因素多步骤的过程，同时伴随着一系列致癌因素所导致的基因突变，以及某些信号通路的异常激活。hedgehog(HH)信号通路参与了正常的胚胎发育过程以及组织的创伤与修复，特别是干细胞的自我更新，但它的异常激活却在多种人类恶性肿瘤中有发生。本文集中介绍HH在癌的发生、增殖、浸润及转移中所起的重要作用，通过对其致癌机制的综述，阐明它将可能成为一个有效治疗靶点，从而为肿瘤的防治提供了更多机遇。
关键词：hedgehog信号通路；PTCH；SMO；Gli；肿瘤

The proceeding of the hedgehog signaling pathway in tumor

LI Xiao-wei， LIU Bing-ya*

Shanghai Institute of Digestive Surgery， Ruijin Hospital， Shanghai Jiaotong University School of Medicine， Shanghai 200025，China

Abstract: Abstract: Carcinogenesis is a complicated multistep process， with a series of genetic mutations caused by carcinogenic agents， and the dysfunction of some signaling pathways， such as hedgehog signaling pathway(HH). HH is involved in the processes of normal embryonic pattern formation and tissue injury and repair， especially it plays a critical role in the stem cell self-renewal. But the abnormal activation of HH can commonly be observed in many human malignant tumors. Here we will focus on its crucial role in the formation， generation， infiltration and metastasis of carcinoma， and deeply discuss the mechanism of its carcinogenesis.
Key words: hedgehog signaling pathway; PTCH; SMO; Gli; carcinoma