《生命科学》 2009, 21(1): 107-111

nm23-H1调控肿瘤侵袭转移分子机制研究进展

叶苏娟，朱　文*

四川大学华西医院生物治疗国家重点实验室，成都 610041

摘　要：摘　要：侵袭转移是恶性肿瘤的重要生物学特征，也是导致肿瘤患者治疗失败和死亡的主要原因。研究表明，nm23基因家族与肿瘤的发生、发展及转移密切相关。其中，nm23-H1是被发现的第一个人类nm23基因，与肿瘤侵袭转移关系极为密切。现将nm23-H1基因调控肿瘤侵袭转移分子机制的研究进展作一综述。
关键词：nm23-H1基因；肿瘤；侵袭；转移；分子机制；肺肿瘤；乳腺肿瘤

Recent advances on the molecular mechanism of nm23-H1-regulated invasion and metastasis of tumors

YE Su-juan， ZHU Wen*

State Key Laboratory of Biotherapy， West China Hospital， Sichuan University， Chengdu 610041， China

Abstract: Abstract: Invasion and metastasis are not only the important traits of malignant tumors， but also the leading cause of failure to treatment for patients and their death. Many researches have shown that nm23 gene family has correlation to the genesis， development and metastasis of various tumors. nm23-H1 gene is the first gene of nm23 genes discovered in human. Furthermore， it has the closest relationship with the invasion and metastasis of tumors. In this review， we summarized the recent research advances on the molecular mechanism of nm23-H1-regulated invasion and metastasis of various tumors.
Key words: nm23-H1 gene; neoplasm; invasion; metastasis; molecular mechanism; lung carcinoma; breast carcinoma