《生命科学》 2009, 21(1): 97-101

bcl-3的研究进展

王少敏*，叶　孟，倪曙民

宁波大学医学院附属医院肿瘤内科，宁波 315020

摘　要：摘　要：bcl-3基因最初发现于B细胞慢性淋巴细胞白血病(B-CLL)的一个亚型，并被认为是其分子特征。研究显示bcl-3蛋白含七个锚蛋白样重复序列，属于IkB家族蛋白，在 NF-kB途径中有着重要的调控作用。此后的研究显示，bcl-3在血液肿瘤及实体肿瘤中均可见过度或失控表达，发挥着促进肿瘤形成的作用，而其正常水平的表达对于正常免疫反应的形成和防止过度的炎症反应也是极其重要的。同时bcl-3也可对促进肿瘤形成的基因进行调控。本文现就bcl-3在这些方面的研究进展作一综述。
关键词：bcl-3；肿瘤；免疫；炎症；癌基因

Advances in the research of bcl-3

WANG Shao-min*， YE Meng， NI Shu-min

The Affiliated Hospital Of Ningbo University， Ningbo 315020， China

Abstract: Abstract: bcl-3 proto-oncogene was originally discovered in a subtype of B-cell chronic lymphocytic leukemia(B-CLL)and was regarded as its character. Amino acid sequence alignment showed that bcl-3 contains seven repeats of anankyrin-like unit and belongs to the IkB family，which modulate the DNA binding activity and subcellular localization of the transcription factor NF-kB. Subsequently the further research showed that bcl-3 is over-expressed or deregulated expressed in other cancer， and can promote oncogenesis. But the proper expression of BCL-3 is important to form normal imunne response and prevent imorderate inflammatory response. bcl-3 also can regulate other oncogene. Now we summarize the recent advances in these fields.
Key words: bcl-3; cancer; immunity; inflammatory; oncogene