《生命科学》 2009, 21(1): 81-85

转录因子Rex-1：结构、表达谱和干性(stemness)调控功能

蹇　锐1，刘　兵2，胡福泉1*，程小星3*

1第三军医大学微生物学教研室，重庆 400038；2解放军307医院肿瘤学研究室，北京 100071；3解放军总医院309临床部，北京 100091

摘　要：摘　要：Rex-1(reduced expression 1)又称Zfp-42(zinc finger protein 42)，是一种酸性锌指结构蛋白，在胚胎干细胞和部分成体干细胞中高表达，并随维甲酸(retinoid acid， RA)诱导干细胞分化而迅速下调。 该分子的结构特点提示其具有转录调控的功能，对决定干细胞的状态和发育阶段发挥重要作用。
关键词：Rex-1；干细胞；分化；转录调控

Transcription factor Rex-1: structure， expression profile and stemness regulatory function

JIAN Rui1， LIU Bing2， HU Fu-quan1*， CHENG Xiao-xing3*

1 Department of Microbiology， Third Military Medical University， Chongqing 400038， China; 2 Laboratory of Oncology， the 307th Hospital of PLA， Beijing 100071， China; 3 309th Clinical Division， PLA General Hospital， Beijing 100091， China

Abstract: Abstract: Rex-1 (reduced expression 1)， also known as Zfp-42(zinc finger protein 42)， encodes a protein containing four repeats of the zinc finger motif and an acidic domain. These structural features imply a possible regulatory function for Rex-1. Expression of Rex-1 is high in embryonic and several adult stem cells， and rapidly reduced after RA-induced differentiation. The unique expression profile of Rex-1 suggests that it may play an important role in deciding the status and fate of stem cells.
Key words: Rex-1; stem cells; differentiation; transcriptional regulation