《生命科学》 2009, 21(1): 43-48

丙型肝炎病毒非结构蛋白NS2的研究进展

龚巧玲1，2，王 建1*，贺福初

1 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，蛋白质组学国家重点实验室，北京 102206； 2 清华大学北京协和医学院－清华大学医学部，北京100005

摘　要：摘 要：丙型肝炎病毒(hepatitis C virus， HCV)是一种严重危害人类健康的病原体，全球感染率约3%，中国普通人群抗HCV阳性率约3.2%。然而，到目前为止，HCV感染还没有有效的治疗方法。近年的研究发现，HCV非结构蛋白NS2在HCV感染中扮演着重要角色，具有许多重要功能。NS2可以在HCV病毒的包装过程中发挥其功能，还可调节宿主细胞的基因表达及凋亡过程。此外，NS2蛋白还可参与NS5A磷酸蛋白的高度磷酸化修饰过程及为感染性HCV病毒粒子产生所必需。本文综述近几年来关于NS2蛋白的研究进展。
关键词：丙型肝炎病毒；非结构蛋白NS2；细胞周期；细胞凋亡

Advance in the research of the nonstructural protein NS2 of hepatitis C virus

GONG Qiao-ling1，2， WANG Jian1*， HE Fu-chu1

1 State Key Laboratory of Proteomics， Beijing Proteome Research Center， Beijing Institute of Radiation Medicine， Beijing 102206， China; 2 Peking Union Medical College， Tsinghua University， Beijing 100005， China

Abstract: Abstract: Hepatitis C virus (HCV) is a major etiologic agent of non-A， non-B hepatitis， which seriously impairs human health. Estimate from WHO places the number of HCV-infected individuals at 170 million， representing nearly 3% of the world抯 population. Anti-HCV positive rate of healthy people in China is 3.2%. However， up to now， there is neither vaccine nor efficient therapy drug available. In recent years， the study of HCV found that non-structural protein NS2 plays an important role in HCV infection. For example， NS2 has a dual function in the HCV replication cycle by acting both as a protease and an essential assembly cofactor， regulate the host cell gene expression and apoptosis， participate in the NS5A protein excessive  phosphorylation modification process and is essential for production of infectious virus. This paper reviews on the progress of the study of NS2 protein in the past few years.
Key words: HCV; NS2; cell apotosis; cell cycle