《生命科学》 2009, 21(1): 7-10
摘 要：摘 要：当代药物设计是通过阐明药物与靶标相互作用的机理，对药物先导化合物进行改造和优化。利用晶体X射线衍射的方法获得药物与靶标复合物的结构，为药物设计提供最直接有力的依据。同步辐射凭借其高强度、低发散性、波长可调谐性等得天独厚的优势，实现了对药物与靶标复合物结构的高通量测定，大大提高了基于结构的药物设计效率。
关键词：药物设计；晶体X射线衍射；同步辐射
Abstract: Abstract: Drug design is based on the mechanisms of the drug and target interaction to achieve optimization of the leads. The structures of drug-target complexes obtained by X-ray crystallography provide direct and convictive evidences for drug design. Synchrotron has the advantages of high intensity， low divergence and tunability， so that it can be used for high-throughput data collection of complex structures， thus improving the efficiency of structure-based drug design.
Key words: drug design; X-ray crystallography; synchrotron
