《生命科学》 2008, 20(5):

F-box蛋白家族及其功能

王秀燕1,孙莉萍1*，张建锋1，李　辉1，吕文清3，张其清1,2*

（1厦门大学生物医学工程研究中心，福建省生物医学工程重点实验室，厦门 361005；2中国医学科学院，中国协和医科大学生物医学工程研究所，天津市生物医学材料重点实验室，天津 300192；3厦门大学抗癌研究中心，厦门 361005）

摘　要：摘　要：F-box蛋白是一类广泛存在于真核生物中，含有F-box结构域的蛋白家族，在泛素-蛋白酶体途径(ubiquitin-proteasome pathway, UPP)中因特异识别底物蛋白而参与细胞周期调控、转录调控、细胞凋亡、细胞信号转导等生命活动。另外，F-box蛋白还通过其他作用方式参与了体内众多生化过程。本文综述了F-box蛋白的结构和作用途径，以及该蛋白参与的多种生理功能，展示了F-box蛋白家族在生命活动中具有广泛而重要的作用，并指出了F-box蛋白将为阐明疾病发生机制提供新的线索，可望成为疾病治疗中药物作用的靶向位点。
关键词：F-box蛋白；泛素-蛋白酶体途径；SCF复合体
中图分类号：Q51　　文献标识码：A

F-box proteins and their functions

WANG Xiu-yan1, SUN Li-ping1*, ZHANG Jian-feng1, LI Hui1, L?Wen-qing3, ZHANG Qi-qing1,2*

(1 Research Center of Biomedical Engineering, Xiamen University, Key Laboratory of Biomedical Engineering of Fujian, Xiamen 361005, China; 2 Institute of Biomedical Engineering, Chinese Academy of Medical Science &Peking Union Medical College, Key La

Abstract: Abstract: F-box proteins are an expanding family of eukaryotic proteins characterized by an 揊-box?motif. They are in charge of substrate specificity in the ubiquitin-proteasome pathway and therefore play a pivotal role in many physiological activities such as cell-cycle progression, transcriptional regulation, programmed cell death and cell signal transduction. In addition, F-box proteins participate in many other biochemical processes through different ways. In this review we focus on the structure and function of F-box proteins and reveal that this protein family has an important role in life. Furthermore, we indicate that F-box proteins are attractive candidates in the disease therapy and drug interaction.
Key words: F-box protein; function; ubiquitin proteasome pathway; SCF complex