《生命科学》 2008, 20(5):

溶瘤单纯疱疹病毒治疗技术及其进展

田 聆, 薛京伦, 贾韦国*

（复旦大学生命科学学院遗传学研究所暨遗传工程国家重点实验室，上海 200433）

摘　要：摘　要：溶瘤病毒治疗是当前肿瘤治疗技术的研究热点，溶瘤单纯疱疹病毒是目前研究最多的，也是抗肿瘤作用最好的溶瘤病毒之一，本文就主要介绍溶瘤单纯疱疹病毒的优势、遗传操作、发展策略、研究进展及靶向性策略等。
关键词：溶瘤病毒; 病毒治疗；基因治疗
中图分类号：R373; R730.59　　文献标识码：A

Oncolytic herpes simplex virus and its advances in cancer therapy

TIAN Ling, XUE Jing-lun, JIA Wei-guo*

(State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China)

Abstract: Abstract: Oncolytic virotherapy represents an emerging modality with tremendous promise for cancer treatment. Among various oncolytic virues, oncolytic herpes simplex virus is one of the most widely explored agents and shows significant anti tumor activity. In this review, we mainly discuss the advantages of oncolytic HSV, the principles of HSV genetic manipulation, the strategies of oncolytic HSV development and targeting, the advances and challenges of oncolytic HSV in cancer therapy.
Key words: oncolytic virus; virotherapy; gene therapy