摘 要：摘 要：瞬时分子信号发生在微区，这些区域通常处于一种非均一非平衡状态。在这个过程中，参与的分子数很少，通常有很大的波动。于是，了解各种分子成分的空间组织结构对理解细胞信号通路非常必要。我们利用蒙特卡洛电脑仿真的方法，结合现实的三维几何构形，来研究亚细胞结构以及神经元和突触的生理学。
关键词：突触传递；蒙特卡洛仿真；异位释放；微区
中图分类号：R338.1 文献标识码：A
Abstract: Abstract: Transient molecular signals occur in microdomains that are typically neither well mixed nor in equilibirum. The number of molecules is often small so that large fluctuations can occur. As a consequence, knowing the spatial organization of the molecular components is essential in understanding cell signaling pathways. We are using Monte Carlo computer simulations that incorporate realistic 3-D geometries to explore the subcellular architecture and physiology of neurons and synapses.
Key words: synaptic transmission; Monte Carlo simulation; ectopic release; microdomain
