《生命科学》 2008, 20(4):

血管内皮细胞微粒研究进展

古秀雯，刘　伟，毛恩强*

（上海交通大学医学院附属瑞金医院外科ICU，上海 200025）

摘　要：摘　要：内皮细胞微粒(endothelial microparticle, EMPs)是内皮细胞活化或凋亡时，从其表面释放的小囊泡，其作为反映内皮细胞功能的新标记物，在炎症反应、心血管疾病和糖尿病等多种疾病中都有所增加。本文就EMP可能的形成机制、组成成分和主要作用作一概述。
关键词：内皮细胞微粒；凝血；炎症；血管生成；血管功能障碍
中图分类号：Q25　　文献标识码：A

Research developments of vascular endothelial microparticles

GU Xiu-wen, LIU Wei, MAO En-qiang*

(Affiliated Ruijin Hospital Surgery ICU, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China)

Abstract: Abstract: Endothelial microparticles (EMPs) are small membrane vesicles that are shed from the surface of endothelial cells in response to activation or apoptosis. As a new marker of endothelial cell function, increased level of EMPs has been documented in several diseases, including inflammatory disorders, cardiovascular diseases, and diabetes mellitus. This review was written to give an outline about the possible formation mechianism, composition and the main function of EMPs.
Key words: endothelial microparticles; blood coagulation; inflammation; angiogenesis; endothelial cell dysfunction