《生命科学》 2008, 20(4):

抗菌肽的研究进展

祝　骥1,高　飞2,易　喻1,陈建澍1,应国清1*

（1浙江工业大学药学院，杭州 310014；2艾博生物医药(杭州)有限公司，杭州310018）

摘　要：摘　要：近年来，由于细菌耐药性问题日趋严峻，开发新型抗菌制剂已迫在眉睫。抗菌肽具有相对分子质量小、对热稳定、抗菌谱广及不同于抗生素的抗菌机制，不产生耐药性，因而具有重要的临床应用价值。本文对天然来源、蛋白质酶解、化学合成及基因工程方法产生的抗菌肽及其研究进展进行了综述。
关键词：抗菌肽；蛋白质酶解；基因工程；化学合成
中图分类号：Q516　　文献标识码：A

Progress on antimicrobial peptides

ZHU Ji1, GAO Fei2, YI Yu1, CHEN Jian-shu, YING Guo-qing1*

(1 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; 2 ABON Biopharm (Hangzhou) Co., Ltd , Hangzhou 310018, China)

Abstract: Abstract: Resistance of microbial pathogens to antibiotics is an increasingly serious problem, which result in urgency for new type antibiotics development. Antimicrobial peptides have great clinical significance due to its character of small molecular weight, high thermal stability, broad-spectrum antimicrobial activity and the antimicrobial mechanisms different from traditional antibiotics. The research advances in antimicrobial peptides  obtained from natural resource, enzymatic digestion of protein, chemical synthesis and gene engineering were summarized in this paper.
Key words: antimicrobial peptide; enzymatic digestion of protein; gene engineering; chemical synthesis