《生命科学》 2008, 20(3):

游离脂肪酸受体蛋白研究进展

曾军英 1,2，孙志洪1,2，谭支良1*

( 1中国科学院亚热带农业生态研究所，长沙 410125；2 中国科学院研究生院，北京 100039）

摘　要：摘　要：游离脂肪酸不仅是人和动物体的一种重要能量来源，也是一种重要的信号分子。最近研究表明，游离脂肪酸受体蛋白在维持机体内的葡萄糖稳衡、脂肪形成、白细胞功能等生理过程中都有重要的作用，对于调控人或动物的营养代谢及疾病发生具有重要生理意义。
关键词：短链脂肪酸；长链脂肪酸；G蛋白偶联受体；信号转导
中图分类号：Q574　文献标识码：A

G protein-coupled receptors for free fatty acids

ZENG Jun-ying1,2, SUN Zhi-hong1,2, TAN Zhi-liang2*

(1 Institute of Subtropical Agricultural Ecology, Chinese Academy of Sciences, Changsha 410125, China; 2 Graduate School of Chinese Academy of Sciences, Beijng 100039, China)

Abstract: Abstract: Free fatty acids (FFAs) are not only an important direct source of energy for human and animal, but also a kind of key signal molecule in variety of physiological and pathophysiological reponses. The latest researches indicated that these G protein-coupled receptors（GPCRs）for FFAs played key roles in glucose homeostasis, adipogenesis, white cell function and  regulation of human and animal nutrition and metabolic syndrome.
Key words:  short chain fatty acid; long chain fatty acid; G protein-coupled receptors; signal transduction