《生命科学》 2008, 20(3):

无机纳米粒子作为基因载体的研究进展

李新新，侯 森，冯喜增*

（南开大学生命科学学院，生物活性材料教育部重点实验室, 天津 300071）

摘　要：摘　要：转染是将具生物功能的核酸转移、运送到细胞内，并使其在细胞内维持生物功能的过程。作为现代生物化学和分子生物学中的一种主要技术手段，转染对于基因治疗有重要的意义。无机纳米粒子作为基因载体受到人们日益广泛的关注，其具有易于制备，可进行多样化的表面修饰等多种优势。本文将概述无机纳米粒子作为基因载体的现状及其对基因表达的影响。
关键词：转染；无机纳米粒子；基因载体；基因治疗
中图分类号：TN383；Q782；R394　　文献标识码：A

Progress of inorganic nanoparticles as gene delivery vectors

LI Xin-xin HOU Sen FENG Xi-zeng*

(The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China)

Abstract:

Abstract: Transfection is defined as the delivery of functional nucleic acids into living cells, maintaining the biological function of the nucleic acids. As an important technique in biochemistry and molecular biology, transfection is meaningful for its potential applications in gene therapy. Inorganic nanoparticles can be used as gene delivery vectors and have received extensive interest due to their various advantages, such as easy preparation and surface-functionalization. This paper reviewed the current researches about inorganic nanoparticles as gene delivery vectors. Their influence on the gene expression was also discussed.

Key words: transfection；inorganic nanoparticles；gene vectors；gene therapy