摘 要：摘 要：表皮干细胞能够维持正常表皮的新陈代谢、毛囊周期循环以及参与创伤情况下创面的修复，皮肤肿瘤的发生也与其密切相关。表皮干细胞的增殖和分化受到严格的调控，了解表皮干细胞增殖与分化的调控机制将有助于治疗脱发、创伤以及皮肤肿瘤等疾病。文章着重概述了Wnt和Bmp信号对于控制干细胞命运的重要作用。
关键词：表皮干细胞；增殖；分化；调控；Wnt；Bmp
中图分类号：Q813 文献标识码：A
Abstract: Abstract: Epithelial stem cell plays pivotal role in maintaining epithelial metabolism, hair follicle cycling, repairing the epidermis on injury, and has close relationship with skin tumorigenesis. Understanding the signaling pathways, which is important for keeping stem cell undifferentiated phenotype, and the mechanism of proliferation and differentiation may help to treat hair loss, wound healing and skin tumors et al. In this paper, we summarize the effect of Wnt signaling and Bmp signaling on the fate of epithelial stem cell.
Key words: epithelial stem cell; proliferation; differentiation; regulation; Wnt; Bmp
