《生命科学》 2008, 20(2):

VEGF与肿瘤血管生成及其在抗肿瘤药物开发中的应用

何 艳，曹以诚*

(华南理工大学生物科学与工程学院，广州510006)

摘　要：摘　要：肿瘤血管生成在肿瘤的形成和转移过程中起到很重要的作用，众多的血管生成因子和抑制因子在肿瘤血管生成中起到调控作用，而血管生成因子(VEGF)是其中很重要的一类，通过研究其在肿瘤血管形成过程的调节机制，找到了一条有效的预防和治疗肿瘤的新途径。本文就肿瘤血管生成、VEGF家族的特性、VEGF在抗肿瘤药物开发中的应用做一综述。
关键词：VEGF；肿瘤血管生成；抗肿瘤药物
中图分类号：Q463;R730.23　　文献标识码：A

VEGF and tumor angiogenesis and its application on anti-tumor drug exploration

HE Yan, CAO Yi-cheng*

(Department of Bioscience and Engineering, South China University of Technology, Guangzhou 510006,China)

Abstract: Abstract:  Angiogenesis plays a great role on tumor growth, metastasis. A lot of angiogenesis  factors and inhibitors regulate angiogenesis. VEGF is the most important one and through the research of the regulatory mechanism of VEGF during tumor angiogenesis , a new effective way to prevent and cure cancer was found. This thesis gives a review on tumor angiogenesis, the features of VEGF family, the application of VEGF on anti-tumor drugs .
Key words: VEGF；tumor angiogenesis；anti-tumor drugs