《生命科学》 2008, 20(1):

COX-2及其抑制剂在肿瘤防治中的作用

向　阳1，孙　敏1，王和勇2*

(1西南大学生命科学学院，重庆 400715；2 同济大学附属上海市肺科医院，上海 200433)

摘　要：摘　要：环氧化酶(cyclooxygenase, COX)是前列腺素合成途径中主要的限速酶之一，参与炎症、发热、出凝血等病理生理过程。COX-2在肿瘤发生发展、转移、凋亡抑制及促进肿瘤血管生成等方面发挥重要作用，已成为肿瘤防治的一个新靶点；COX-2及其抑制剂在肿瘤预防、放疗、化疗、生物疗法中具有广阔应用前景。本文就COX-2及其抑制剂在肿瘤防治中的进展作一详细综述。
关键词：COX-2；抑制剂；肿瘤预防；肿瘤治疗
中图分类号：Q554.6; R730.1　　文献标识码：Ａ

The function of COX-2 and it’s inhibitors in tumor prevention and treatment

XIANG Yang1, SUN Min1, WANG He-yong2*

(1 School of Life Science, Southwest University, Chongqing 400715, China; 2 Pulmonary Hospital, Tongji University, Shanghai 200433, China)

Abstract: Abstract: Cyclooxygenase is the main rate-limiting enzyme in the prostaglandin synthesis, which participates in inflammation, fever, hemoglutination and so on. COX-2 plays a vital role in the tumor occurrence, angiogenesis, metastasis as well as apoptosis inhibition. Therefore, COX-2 has become a new target in tumor treatment. COX-2 and its inhibitors have a broad prospect in the tumor prevention, chemotherapy, radiotherapy and biotherapy. This article reviews recent research progress of COX-2 and its inhibitors in tumor preventing and controlling.
Key word: COX-2; inhibitor; tumor prevention; cancer therapy