《生命科学》 2007, 19(5):

神经肽Y参与痛觉调制的研究进展

李　莉，郭　媛，赵　晏*

(西安交通大学环境与疾病相关基因教育部重点实验室，西安交通大学医学院生理学与病理生理学系，西安710061)

摘　要：摘　要：神经肽Y (NPY)是中枢神经系统内含量最多的神经肽之一，它参与机体多种生理活动。近年来，对不同痛模型中NPY作用的研究表明，NPY可能通过激活脊髓和脊髓上水平的Y1受体或拮抗背根节的Y2受体发挥镇痛作用，此类研究将为NPY及其受体激动剂在镇痛中的应用提供重要的理论基础。本文就NPY及其Y1、Y2受体在痛觉调制中的作用作一简要综述。
关键词：神经肽Y；神经肽；痛觉；中枢神经系统
中图分类号：Q426；R338　　文献标识码：A

Recent advances in study on the role of NPY in pain modulation

LI Li, GUO Yuan, ZHAO Yan*

(Key Laboratory of Environment and Gene Related to Disease, Ministry of Education, Xi{$39}an Jiaotong University;Department of Physiology and Pathophysiology, Medical School, Xi{$39}an Jiaotong University, Xi{$39}an 710061, China)

Abstract: Abstract: Neuropeptide Y ( NPY ) is one of the most abundant neuropeptides in the central nervous system (CNS), which is involved in lots of physiological actions. Recently, there are many articles about NPY targeting its roles in pain modulation by means of different animal models. It is shown that the analgesic effect could be induced by either activating the Y1 receptor locating in the CNS or inhibiting the Y2 receptor in the DRG. These studies would provide important rationale for development and application of new type analgesic drugs aiming directly at Y1/Y2 receptor. This review will summarize the roles of NPY in pain processing and related mechanisms in these researches.
Key words: NPY; neuropeptide; pain; CNS