《生命科学》 2007, 19(5):

乳腺癌蛋白质组研究进展

张丽军1*，谭丁桃2

(1复旦大学附属公共卫生临床中心，上海201508；2 湖南涟源办事处农技站，涟源417100)

摘　要：

摘　要：乳腺癌是发生在乳房腺上皮组织的恶性肿瘤，其发病率占女性恶性肿瘤首位。近年来，蛋白质组研究广泛深入乳腺癌发病机理、临床早期诊断和治疗等各个方面。本文比较系统地综述了乳腺蛋白质组研究的样品处理、研究技术和研究成果。
关键词：乳腺癌；蛋白质组；激光捕获显微切割(LCM)；质谱
中图分类号：Q51；R737.9　　文献标识码：A

Progress in proteome research of breast cancer

ZHANG Lijun1*, TAN Dingtao2

(1 Affiliated Public Health Clinical Center, Fudan University, Shanghai 201508, China; 2 Agricultural Technology Station, Lianyuan office, Lianyuan 417100, China)

Abstract: Abstract: Breast cancer is a malignant cancer that is developed in breast epithelial tissue. The mortality of breast cancer is at the first place in female malignant cancers. In recent years, proteome research is widely used in pathogenesis, clinical early diagnosis and treatment of breast cancer. In this review, we systematically summarized the progress of proteome research in sample treatment, experiment technology and research achievements of breast cancer.
Key words: breast cancer; proteomics; laser capture microdissection(LCM); mass spectrometry