摘 要：摘 要：胚胎干细胞(ES细胞)来源于早期发育的胚胎，具有分化为任何细胞类型的多能性，因此具有巨大的基础研究及潜在的应用前景。目前认为ES细胞主要通过一些外源性信号分子的作用及某些重要的内源性转录因子的表达共同起作用来达到其维持多能性的目的。外源性信号分子LIF、BMP4 以及Wnt等介导的信号传导通路与内源性转录因子Oct4、Nanog、Sox2、FoxD3等共同起作用来抑制那些促进ES细胞分化的基因表达和激活那些有助于维持ES细胞多能性维持的基因表达，进而形成一个相互调控和依存的基因调控网络共同维持ES细胞的多能性。
关键词：胚胎干细胞；自我更新；分化
中图分类号：Q813 文献标识码：A
Abstract: Abstract: Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF, BMPs and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the "pluripotent genes."In combination with intrinsic transcription factors such as FoxD3, Nanog, Oct4 , these factors form a regulatory network to support or limit each other{$39}s expression level, which maintain the properties of ES cells.
Key words: embryonic stem cells; self-renewal; differentiation
