摘 要：摘 要：p53主要通过两条途径诱导细胞凋亡：p53作为转录因子，促进细胞凋亡的靶基因的表达上调，如PUMA、NOXA、PIDD、p53AIP1、COP1等，并通过这些蛋白参与内源和外源凋亡途径；另一方面，胞浆中的p53能转位到线粒体，激活内源性的线粒体途径，促进凋亡。后者已成为研究p53促凋亡机制的热点。本文就p53对转录非依赖活性诱导细胞凋亡途径的研究进展作一概述。
关键词：p53；线粒体；转录非依赖凋亡；细胞凋亡
Abstract: Abstract: p53 exerts its tumor-suppressing activity through complicated apoptotic mechanisms. Besides as a transcriptional factor for induction of multiple apoptotic-associated gene expression, p53 also triggers apoptosis through transcription-independent pathways. Cytosol p53 protein targets mitochondrial membrane through interaction with anti- or pro-apoptotic Bcl2 family members and induces the permeabilization of mitochondrial membrane, which in turn initiates intrinsic mitochondria-mediated apoptotic pathway. This review focuses on the mechanisms of its unexpected transcription-independent pro-death programs at mitochondria and highlights the remarkable relationship between transcription-dependent and -independent apoptotic pathways.
Key words: p53; mitochondria; transcription-independent; apoptosis
