生命科学

《生命科学》 2007, 19(4):

一氧化氮在炎性疼痛中的作用

李　其，洪炎国^*

(福建师范大学生命科学学院神经生物学实验室，福州350108)

摘　要：

摘　要：一氧化氮(nitric oxide，NO)是细胞内重要的信使分子和神经递质，它参与多种生命活动，包括炎性疼痛。NO对炎性疼痛的发展和维持起到了重要的作用。研究NO在疼痛中所起到的作用及其机制有利于阐明痛觉生理和发现疼痛治疗的新手段。目前研究表明，脊髓水平NO参与炎性疼痛调制的可能机制主要有NO/cGMP途径、参与调控即刻早期基因、与其他神经递质的协同作用。另外研究表明，3种类型的一氧化氮合酶(nitric oxide synthases，NOS)在炎性疼痛过程中被激活或者有不同程度的增强表达。
关键词：一氧化氮；一氧化氮合酶；炎性痛
中图分类号：Q426；R364.5　　文献标识码：A

The effect of nitric oxide in inflammatory pain

LI Qi, HONG Yanguo^*

(College of Life Science, Fujian Normal University, Fuzhou 350108, China)

Abstract:

Abstract: Nitric oxide (NO) is involved in the pathological process of inflammatory pain and plays a critical role in the development and maintenance of hyperalgesia. The study of the effect and mechanism of nitric oxide can help to elucidate physiology of inflammatory pain and discover the clinical therapy. Several lines of evidence have been accumulated to suggest that nitric oxide produce inflammatory pain via NO/cGMP pathway, expression of immediate early genes, and interacting with other neurotransmitter. Three isoforms of NOS are found and facilitate the induction of pain. They exert the different effects on the development and maintenance of inflammatory pain.
Key words: nitric oxide; nitric oxide synthases; inflammatory pain