《生命科学》 2004, 16(5):

非侵入性脑内给药

吴少平^1,2, 孙曼霁^1*

1 军事医学科学院毒物药物研究所，北京 100850;2 北京市疾病预防控制中心，北京 100013

摘　要：摘　要：血脑屏障使许多具有中枢神经活性的药物无法到达脑部发挥作用，非侵入性脑内给药因对机体无创伤而受到研究者广泛关注。本文介绍了血脑屏障的物质转运系统以及经鼻粘膜、渗透性血脑屏障开放、纳米粒载体和转运载体法等非侵入性脑内给药方法的机制和特点。
关键词：血脑屏障; 药物转运; 非侵入性

Non-invasive drug delivery into brain

WU Shao-Ping^1,2, SUN Man-Ji^1*

1 Institute of Toxicology and Medicine, Academy of Military Medical Sciences, Beijing 100850, China;2 Beijing Center for Disease Prevention and Control, Beijing 100013, China

Abstract: Abstract: The blood-brain barrier (BBB) restricts the transport action and action of many central neuroactive drugs in the brain.Thus the non-invasive drug delivery to brain has been following with great interest. In this paper, the mechanism and characteristics of the non-invasive drug delivery through nasal mucosa, osmotic opening of the BBB, nanoparticulate and transporter vectors is introduced and discussed.
Key words: blood-brain barrier; drug delivery; non-invasive