《生命科学》 2004, 16(5):

神经细胞粘附分子结构特征和生理功能

邓朝晖, 余争平, 王登高

第三军医大学预防系劳动卫生教研室, 重庆 400038

摘　要：摘　要：神经细胞粘附分子是一类调节细胞与细胞、细胞与细胞外基质间粘附作用的膜表面糖蛋白，主要有NCAM-180、NCAM-140、NCAM-120三种形式，多与PSA结合在一起。在神经系统中，NCAM的表达具有时间和空间特异性，最主要的作用为调节神经系统的可塑性，这种作用可能是通过PSA-NCAM对AMPA的调节作用，主要是通过调节蛋白激酶的表达和细胞内Ca2+浓度来实现的。
关键词：神经细胞粘附分子;  AMPA受体

The structure and physiological function of neural cell adhesion molecules

DENG Zhao-Hui, YU Zheng-Ping, WANG Deng-Gao

Department of Occupational Health, Third Military Medical University, Chongqing 400038, China

Abstract: Abstract: Neural cell adhesion molecules(NCAMs) are cell surface glycoproteins that appear to mediate cell-cell, cell-extracellular matrix adhesion. NCAMs, largely attached with polysialic acid(PSA), exist in three major different polypeptide forms with apparent molecular weight 180, 140, 120kD. In nervous system, NCAM is expressed in a defined temporal and spatial pattern. PSA-NCAM plays an important role in the formation of neural plasticity by regulating AMPA receptor formation, mainly by regulating the expression of the protein kinase and the intracellular Ca2+ level.
Key words: neural cell adhesion molecule;  AMPA receptor