摘 要：摘 要：聚乙二醇及其衍生物是具有许多优良性质的高分子化合物，由于良好的生物相容性、无毒、无免疫原性, 广泛用于生物医学领域。本文总结聚乙二醇的发展历史和新一代聚乙二醇的特点，阐述聚乙二醇化修饰的目的，特别是在抗原修饰、血型改造和细胞移植等方面的应用，重点对聚乙二醇在药物缓释方面的应用进行了系统的综述。
关键词：聚乙二醇；抗原；药物；缓释
Abstract: Abstract: Polyethylene glycol (PEG) and its derivatives are a group of compounds with high molecular weight as well as excellent properties such as biocompatibility, non-toxicity and non-immunogenicity. It was widely used in the field of biomedical science. This review expounded history of PEG development, characters of new generation of PEG and purpose of PEG modification, especially in the application of blood conversion and cell transplantation. The use of agent-carrying system based on PEG modification in the drug sustained-release was also discussed.
Key words: polyethylene glycol; antigen; drug; control release
