摘 要：摘 要：14-3-3蛋白是高度保守的、所有真核生物细胞中都普遍存在的、在大多数生物物种中由一个基因家族编码的一类蛋白调控家族。它几乎参与生命体所有的生理反应过程，人们在各种组织细胞中发现了各种不同的14-3-3蛋白。作为与磷酸丝氨酸/苏氨酸结合的第一信号分子，14-3-3蛋白在细胞的信号转导中起着至关重要的作用，尤其是它直接参与调节蛋白激酶和蛋白磷酸化酶的活性，被称为蛋白质与蛋白质相互作用的"桥梁蛋白"；它可以与转录因子结合形成复合体，调节相关基因的表达。一些研究表明，14-3-3蛋白调控机制的紊乱可以直接导致疾病的发生，在临床上14-3-3蛋白常常可以作为诊断的标志物。
关键词：14-3-3蛋白；分子结构；信号转导；蛋白激酶
Abstract: Abstract: 14-3-3 proteins are a family of highly conserved regulatory molecules expressed in all eukaryotic cells, which are coded by a superfamily gene and involved in diverse physiological processes. As the first signaling molecules to be identified as discrete phosphoserine/threonine binding molecules, 14-3-3 proteins play critical roles in cell signaling events that control progress through the cell cycle, transcriptional alterations in response to environmental cues, and programmed cell death，especially, they regulate the activity of protein kinases and phospholipases directly and are known as “bridge protein”, Some researches suggest the disorder of 14-3-3s regulatory mechanism can lead to diseases, so 14-3-3 protein can be as a marker applied for clinical diagnosis.
Key words: 14-3-3 proteins; molecular structure; signal transduction; protein kinase
