《生命科学》 2026, 38(3): 531-539

慢性内脏痛的5-羟色胺受体-TRP通道互作机制

吴艳艳^1,2 , 边对对¹ , 黄雨莹¹ , 杨亮^1,2 , 姜鸣^1,2 , 刘霞^1,2,* , 白占涛^1,2,*

¹延安大学生命科学学院/多肽资源药物研究中心，延安716000 ²陕西省区域生物资源保育与利用工程技术研究中心，延安716000

摘　要：

慢性内脏痛是胃肠道疾病的重要表征，长期的疼痛伴随患者出现焦虑、抑郁等心理问题，目前仍缺乏有效的治疗手段。五羟色胺（5-hydroxytryptamine, 5-HT）受体亚型多，分布广，广泛参与疼痛发生和镇痛作用。瞬时受体电位通道（transient receptor potential channels, TRP channels）激活和传递神经信号，在伤害感觉产生、传递发挥作用。该综述旨在阐述5-HT受体及TRP通道在不同组织动态分布组合的稳态互作机制在慢性内脏痛中的研究，以期建立5-HT受体-TRP通道亚型稳态互作靶向的慢性内脏痛诊疗新策略。

通讯作者：刘霞 , Email:xliu@yau.edu.cn 白占涛 , Email:ztbai@yau.edu.cn

Mechanisms of 5-hydroxytryptamine receptor-TRP channel interactions in chronic visceral pain

WU Yan-Yan^1,2 , BIAN Dui-Dui¹ , HUANG Yu-Ying¹ , YANG Liang^1,2 , JIANG Ming^1,2 , LIU Xia^1,2,* , BAI Zhan-Tao^1,2,*

¹School of Life Science & Research Center for Natural Peptide Drugs, Yan'an University, Yan'an 716000, China ²Shaanxi Engineering & Technological Research Centre for Conservation &Utilization of Regional Biological Resources, Yan'an 716000, China

Abstract:

Chronic visceral pain (CVP), characterized by visceral hypersensitivity and frequently comorbid with affective disorders, represents a significant clinical challenge with limited therapeutic options. This review aims to summarize the research progress on the interaction mechanism between 5-hydroxytryptamine (5-HT)/its receptors and Transient Receptor  Potential (TRP) channels in chronic visceral pain (CVP) to provide a theoretical basis for understanding its mechanisms and developing treatments. The article systematically reviews the complex pathogenesis of CVP, associated with chief conditions  like irritable bowel syndrome (IBS). It details the peripheral and central nervous system mechanisms involving dorsal root  ganglia, spinal sensitization, and specific brain circuits (e.g., PVH, PVT). A core focus is the synthesis, release, and receptor  classification (5-HT1R-5-HT7R) of 5-HT, and the expression and function of key TRP channels (e.g., TRPA1, TRPV1) in CVP. Crucially, it synthesizes emerging evidence of their functional crosstalk, such as TRP channel-mediated 5-HT release  from enterochromaffin cells (TRPA1/TRPM2) and the collaborative role of 5-HT receptors and TRP channels in modulating neuronal excitability and pain signaling of visceral hypersensitivity by 5- HT2B and TRPV1. We propose that the interaction  between 5-HT/its receptors and TRP channels is crucial in CVP pathogenesis. Targeting this crosstalk, particularly in peripheral and central sensitization pathways, represents a promising therapeutic strategy. Future research should further  elucidate the precise molecular and circuit-level mechanisms to facilitate the development of novel, effective analgesics for CVP.

Communication Author：LIU Xia , Email:xliu@yau.edu.cn BAI Zhan-Tao , Email:ztbai@yau.edu.cn