《生命科学》 2025, 37(12): 1688-1696

三磷酸腺苷酶家族蛋白2在肿瘤中的研究进展

胡　婧¹ , 张俊芳^1,2,3,*

¹上海海洋大学水产种质资源发掘与利用教育部重点实验室，上海 201306 ²上海海洋大学水产科学 国家级实验教学示范中心，上海 201306 ³临港新片区海洋生物医药科技创新型平台，上海 201306

摘　要：

三磷酸腺苷酶家族蛋白2 (ATPase family AAA+domain-containing protein 2, ATAD2) 是ATP 酶家族
中一种依赖ATP 的染色质重塑酶，可以作为转录因子的共激活因子参与染色质重塑、基因转录调控、DNA复制和修复等多种生理过程。ATAD2 在肺癌、结直肠癌、宫颈癌等多种恶性肿瘤中高表达，是这些肿瘤的潜在调控靶点。近年来对ATAD2 在肿瘤中的作用和机制有了深入的研究，发现ATAD2 能通过不同途径调控肿瘤发生和肿瘤细胞增殖、迁移和凋亡等恶性行为，同时也在肿瘤耐药及免疫应答方面发挥重要调控作用，这对推进肿瘤靶向治疗或免疫治疗具有重要的临床意义。本文就近年来ATAD2 在恶性肿瘤领域的相关研究成果加以综述，以明确ATAD2 在恶性肿瘤领域中的最新诊疗价值。

通讯作者：张俊芳 , Email:jfzhang@shou.edu.cn

Research progress of ATPase family AAA⁺domain-containing protein 2 in tumors

HU Jing¹ , ZHANG Jun-Fang^1,2,3,*

¹Key Laboratory of Aquatic Germplasm Resources Exploration and Utilization, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China ²National Experimental Teaching Demonstration Center of Aquatic Science, Shanghai Ocean University, Shanghai 201306, China ³Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai 201306, China

Abstract:

ATPase family AAA⁺domain-containing protein 2 (ATAD2) is an ATP-dependent chromatin remodeling enzyme among the ATPase family. As a co-activator of transcription factor, ATAD2 participates in various physiological processes such as chromatin remodeling, gene transcription regulation, DNA replication and repair. ATAD2 is highly expressed in various malignant tumors such as lung cancer, colorectal cancer, and cervical cancer, and is a potential regulatory target for these tumors. In recent years, the role and mechanism of ATAD2 in tumors have been studied in depth. It has been found that ATAD2 can regulate malignant behaviors such as tumorigenesis and tumor cell proliferation, migration and apoptosis through different ways, and  simultaneously plays an important regulatory role in tumor drug resistance and immune response, suggesting significant clinical implications for advancing tumor targeted therapy or immunotherapy. This paper reviews the related achievements of ATAD2 research on malignant tumors in recent years to clarify the latest diagnostic and therapeutic value of ATAD2 against
malignant tumors.

Communication Author：ZHANG Jun-Fang , Email:jfzhang@shou.edu.cn