《生命科学》 2025, 37(10): 1339-1349

CaMKII在精神疾病中的研究进展

黄文兵^1,2 , 舒　尹^1,2 , 魏思琦^1,3 , 闵邓君^1,3 , 李自成^1,2,*

¹三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002 ²三峡大学基础医学院，宜昌 443002 ³三峡大学健康医学院，宜昌 443002

摘　要：

常见的精神疾病包括抑郁、焦虑、双相情感障碍和精神分裂症等。伴随现代社会高速发展，社会压力与日俱增，精神疾病的发病率亦呈明显上升趋势。钙/ 钙调蛋白依赖性蛋白激酶II (calcium/Calmodulin- dependent protein kinase II, CaMKII) 可通过作用于钙信号级联反应途径，参与调控体内生物学功能或疾病发生发展。目前，CaMKII 相关研究越来越广泛且深入，其在神经精神疾病中的调控作用受到广泛关注。本文将对CaMKII 在焦虑、抑郁等精神疾病中的研究进展及相关病理生理机制进行综述。

通讯作者：李自成 , Email:zichengli@ctgu.edu.cn

Research progress of CaMKII in mental disorders

HUANG Wen-Bing^1,2 , SHU Yin^1,2 , WEI Si-Qi^1,3 , MIN Deng-Jun^1,3 , LI Zi-Cheng^1,2,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China ²Basic Medical College, China Three Gorges University, Yichang 443002, China ³College of Medicine and Health Sciences, China Three Gorges University, Yichang 443002, China

Abstract:

Common mental disorders include depression, anxiety, bipolar disorder, and schizophrenia, among others. The rapid development of modern society and its accompanying social pressures have led to a marked increase in the prevalence of mental disorders. Calcium/calmodulin-dependent protein kinase II (CaMKII) can participate in the regulation of various biological functions or the development of diseases by acting on the calcium signaling cascade pathway. Currently, research on CaMKII is growing, and its role in regulating neuropsychiatric diseases is gaining increasing attention. This article reviews the research progress and related  pathophysiological mechanisms of CaMKII in anxiety, depression, and other mental disorders.

Communication Author：LI Zi-Cheng , Email:zichengli@ctgu.edu.cn