《生命科学》 2025, 37(10): 1312-1321

胰岛类器官治疗1型糖尿病：前沿探索与临床应用

陈枕枕 , 宋小平 , 王雅洁 , 蔡晶晶^*

安徽第二医学院药学院，合肥 230000

摘　要：

胰岛类器官(pancreatic islet organoids, PIOs) 可以在体外由干细胞诱导分化获得，其在受到高浓度葡萄糖刺激时能够分泌胰岛素，因此被认为是治疗1 型糖尿病(type 1 diabetes mellitus, T1DM) 的可行方案。本文通过系统梳理PIOs 治疗T1DM 的前沿探索和临床应用，旨在为后续研究提供全面参考，推动该领域不断发展，加速PIOs 治疗T1DM 的临床应用转化，以期为患者带来更有效的治疗选择，改善其生活质量和预后。

通讯作者：蔡晶晶 , Email:caijingjing@ahyz.edu.cn

Pancreatic islet organoids for type 1 diabetes mellitus treatment: frontier exploration and clinical application

CHEN Zhen-Zhen , SONG Xiao-Ping , WANG Ya-Jie , CAI Jing-Jing^*

School of Pharmacy, Anhui Institute of Medicine, Hefei 230000, China

Abstract:

Pancreatic islet organoids (PIOs), which can be derived in vitro through the induced differentiation of stem cells, are capable of secreting insulin in response to high-glucose stimulation. Consequently, they are regarded as a promising therapeutic strategy for type 1 diabetes mellitus (T1DM). This article systematically reviews the current research advancements and clinical applications of PIOs in treating T1DM, aiming to provide a comprehensive reference for future studies, promote ongoing progress in this field, accelerate the clinical translation of PIO-based therapies for T1DM, and ultimately offer patients more effective treatment options to improve their quality of life and prognosis.

Communication Author：CAI Jing-Jing , Email:caijingjing@ahyz.edu.cn