《生命科学》 2025, 37(10): 1302-1311

AMPK生物学功能及参与环境胁迫和胁迫记忆的研究进展

杨天雅 , 王洪涛 , 赵永政 , 马文霞 , 马玉彬^*

中国海洋大学海洋生物遗传学与育种教育部重点实验室，青岛 266003

摘　要：

单磷酸腺苷活化蛋白激酶(adenosine monophosphate-activated protein kinase, AMPK) 作为重要的能量传感器，在保持机体代谢平衡方面发挥着重要作用。AMPK 通过感知细胞能量状态并调控多种代谢途径，参与代谢调节、细胞自噬、凋亡和氧化应激等过程调控。本文总结了AMPK 蛋白的结构、活性调节、生物学功能及其参与环境胁迫和胁迫记忆的相关研究进展，并对未来的研究方向进行了展望。

通讯作者：马玉彬 , Email:mayubin@ouc.edu.cn

The biological function of AMPK and its involvement in environmental stress and stress memory

YANG Tian-Ya , WANG Hong-Tao , ZHAO Yong-Zheng , MA Wen-Xia , MA Yu-Bin^*

Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao 266003, China

Abstract:

Adenosine monophosphate-activated protein kinase (AMPK), serving as a vital energy sensor, plays a crucial role in maintaining metabolic homeostasis. By sensing cellular energy status and regulating multiple metabolic pathways, AMPK participates in metabolic regulation, autophagy, apoptosis, oxidative stress, and other processes. This article focuses on current research advancements regarding the structure, activity regulation, biological functions of AMPK protein, as well as its involvement in environmental stress and stress memory, and finally looks forward to the future research directions.

Communication Author：MA Yu-Bin , Email:mayubin@ouc.edu.cn