《生命科学》 2025, 37(9): 1150-1159

辐射性脑损伤机制及与神经退变再生关系探讨

韩颢雪¹ , 李彦姝^2,*

¹中国医科大学第二临床学院，中国医科大学附属盛京医院，沈阳 110004 ²中国医科大学生命科学学院分子细 胞生物学教研室，教育部医学细胞生物学重点实验室暨国家卫生健康委细胞生物学重点实验室，沈阳 110122

摘　要：

电离辐射导致的辐射性脑损伤(radiation-induced brain injury, RBI) 是颅内肿瘤放射治疗后常见的一种慢性并发症，具有潜在不可逆性，其主要特征包括脑萎缩、脑组织坏死及认知功能障碍，显著影响肿瘤患者的生活质量及预后。当前学科研究对神经再生与退变的动态交互机制关注不足，本文首次提出基于辐射性脑损伤与该机制之间协同调控的治疗策略、具体机制及未来展望，以期为临床提供新的辐射脑损伤治疗思路和方法。

通讯作者：李彦姝 , Email:yslcmu@163.com

Radiation-induced brain injury: mechanisms of neurodegeneration and regeneration and potential therapeutic strategies

HAN Hao-Xue¹ , LI Yan-Shu^2,*

¹The Second Clinical College of China Medical University, Shengjing Hospital of China Medical University, Shenyang 110004, China ²Department of Cell Biology, Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, China Medical University, Shenyang 110122, China

Abstract:

Radiation-induced brain injury (RBI) is a common chronic complication after radiotherapy for  intracranial tumors and is potentially irreversible. Its main features include brain atrophy, brain tissue necrosis and cognitive dysfunction, which significantly affect the quality of life and prognosis of tumor patients. Current research  in this discipline has paid insufficient attention to the dynamic interaction mechanism between neuroregeneration  and degeneration, and this paper proposes for the first time a therapeutic strategy based on the synergistic regulation  between radiation brain injury and its specific mechanism and future outlook, with a view to provide new  therapeutic ideas and methods for clinical practice.

Communication Author：LI Yan-Shu , Email:yslcmu@163.com