《生命科学》 2025, 37(9): 1125-1135

低氧与氧化还原平衡耦合在组织再生中的作用

柳瑞璇^1,2 , 周　炳^1,3,*

¹北京航空航天大学医学科学与工程学院，北京 100191 ²北京航空航天大学生物与医学工程 学院，北京 100191 ³北京航空航天大学北京大数据精准医学先进创新中心，北京 100191

摘　要：

在神经系统中，中枢神经或周围神经损伤引发线粒体功能障碍，导致能量代谢紊乱，继而出现氧化应激和炎症反应，使神经再生极为困难。研究表明，低氧环境广泛存在于组织再生、伤口愈合、免疫反应和肿瘤生长过程中。在低氧条件下，细胞通过代谢重编程适应能量需求和代谢物的重新分配，并调节关键代谢物来维持氧化还原平衡。因此，低氧环境下的代谢适应与氧化还原平衡是组织再生的关键。本文综述了低氧与氧化还原平衡在再生过程中的代谢耦合机制，为组织再生，尤其是神经再生的研究提供新思路。

通讯作者：周　炳 , Email:zhoub2@hotmail.com

The role of hypoxia and redox balance coupling in tissue regeneration

LIU Rui-Xuan^1,2 , ZHOU Bing^1,3,*

¹School of Medicine and Engineering, Beihang University, Beijing 100191, China ²School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China ³Beijing Advanced Innovation Center for Big Data- Based Precision Medicine, Beihang University, Beijing 100191, China

Abstract:

In the nervous system, central or peripheral nerve injuries induce mitochondrial dysfunction, resulting in energy metabolism disorders, which subsequently cause   oxidative stress and inflammatory responses, making nerve regeneration extremely difficult. Studies have shown that hypoxic environments are widely present in tissue regeneration, wound healing, immune responses, and tumor growth. Under hypoxic conditions, cells adapt to energy demands and the redistribution of metabolites through metabolic reprogramming and regulate key metabolites to maintain redox balance. Therefore, adaptation and redox balance in hypoxic environments are crucial for tissue regeneration. This review focuses on the metabolic coupling mechanisms of hypoxia and redox balance in the regeneration process, providing new insights for research on tissue regeneration, particularly nerve regeneration.

Communication Author：ZHOU Bing , Email:zhoub2@hotmail.com