《生命科学》 2025, 37(9): 1093-1108

SLC7A11在胶质瘤中的研究进展

张玉波^1,2 , 田国鹏^1,2 , 刘　凯^1,2 , 袁国强^1,2,3 , 潘亚文^1,2,3,*

¹兰州大学第二临床医学院，兰州 730030 ²兰州大学第二医院神经病学 研究所，兰州 730030 ³兰州大学第二医院神经外科，兰州 730030

摘　要：

SLC7A11 ( 也称为xCT) 是一种关键的氨基酸转运蛋白，主要负责胱氨酸和谷氨酸的跨膜运输。近年来，其在胶质瘤中的研究引起了广泛关注。研究表明，SLC7A11 在胶质瘤细胞中的表达显著上调，且与肿瘤的生长、侵袭及耐药性密切相关。通过调控SLC7A11 的表达或功能，可以影响胶质瘤细胞的代谢途径，从而抑制肿瘤的进展。目前，针对SLC7A11 的靶向治疗策略正在探索中，为胶质瘤的治疗提供了新的方向。本文综述了SLC7A11 在胶质瘤中的研究进展，旨在为其分子机制研究及临床应用提供理论依据。

通讯作者：潘亚文 , Email:pyw@lzu.edu.cn

Research progress of SLC7A11 in glioma

ZHANG Yu-Bo^1,2 , TIAN Guo-Peng^1,2 , LIU Kai^1,2 , YUAN Guo-Qiang^1,2,3 , PAN Ya-Wen^1,2,3,*

¹The Second Medical College of Lanzhou University, Lanzhou 730030, China ²Institute of Neurology, The Second Hospital of Lanzhou University, Lanzhou 730030, China ³Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou 730030, China

Abstract:

SLC7A11, also known as xCT, is a crucial amino acid transporter primarily responsible for the transmembrane transport of cystine and glutamate. In recent years, its role in gliomas has attracted significant attention. Research indicates that the expression of SLC7A11 is markedly upregulated in glioma cells, which may  be closely linked to tumor growth, invasion, and drug  resistance. By modulating the expression or function of SLC7A11, it is possible to influence the metabolic  pathways of glioma cells, thereby inhibiting tumor progression. Furthermore, SLC7A11 plays a role in regulating amino acid metabolism within the microenvironment of glioma, potentially promoting malignant transformation by affecting interactions between the tumor and surrounding tissues. Currently, therapeutic strategies targeting SLC7A11 are under exploration, offering promising new directions for glioma treatment. Here we riview the research progress on  SLC7A11 in glioma, aiming to provide theoretical basis for further elucidating the molecular mechanisms and   potential clinical applications of SLC7A11 in glioma.

Communication Author：PAN Ya-Wen , Email:pyw@lzu.edu.cn