《生命科学》 2025, 37(9): 1085-1092

绿原酸治疗心力衰竭作用机制的研究进展

薛文轩¹ , 王　征² , 武 雪^3,*

¹陕西中医药大学基础医学院，咸阳 712046 ²陕西省中药资源产业化协同创新 中心，咸阳 712046 ³陕西中医药大学医学科研中心，咸阳 712046

摘　要：

心力衰竭(heart failure, HF) 作为心血管疾病的终末阶段，是导致人类死亡的主要因素之一。尽管当前临床上治疗心力衰竭的药物已趋于标准化，但患者死亡率仍居高不下，亟需突破性治疗策略。绿原酸(chlorogenic acid, CGA) 作为金银花的主要活性成分，对多种心血管系统疾病具有治疗潜力。本文旨在从调节心肌细胞代谢、降低炎症反应、减轻氧化应激反应、抗心肌纤维化、自噬调节、抗凋亡、抑制铁死亡等方面综述绿原酸治疗心力衰竭的潜在机制，以期为心血管疾病的治疗及新药研发提供科学依据。

通讯作者：武 雪 , Email:wuxue0820@163.com

Advances in the mechanisms of chlorogenic acid against heart failure

XUE Wen-Xuan¹ , WANG Zheng² , WU Xue^3,*

¹School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China ²Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Xianyang 712046, China ³Medical Research Center of Shaanxi University of Chinese Medicine, Xianyang 712046, China

Abstract:

As the end stage of cardiovascular disease, heart failure (HF) remains one of the leading causes of human mortality. Although current pharmacological therapies for HF have been largely standardized in clinical practice,  patient mortality rates persist at elevated levels,  necessitating breakthrough advancements in therapeutic strategies. Chlorogenic acid (CGA), the principal bioactive constituent of Lonicera japonica, has demonstrated therapeutic potential for various cardiovascular disorders. This review aims to comprehensively summarize the potential mechanisms underlying CGA's cardioprotective effects against HF, focusing on its multifaceted actions including modulation of myocardial cell metabolism, attenuation of inflammatory responses, alleviation of oxidative stress, inhibition of cardiac fibrosis, autophagy regulation, anti-apoptotic effects, and ferroptosis suppression. These mechanistic insights may provide a scientific foundation for optimizing cardiovascular disease management and facilitating novel drug development.

Communication Author：WU Xue , Email:wuxue0820@163.com