摘 要：摘 要：胰高血糖素样肽1 (glucagon-like peptide-1, GLP-1)与胰岛素分泌和糖代谢调节密切相关。GLP-1与其受体(GLP-1 receptor, GLP-1R)结合后，主要通过cAMP和PI3K两条信号途径，促进胰岛素的分泌，刺激胰岛b细胞的增殖和分化。对GLP-1R结构和信号传导机制的研究，有助于了解其在糖尿病病理进程中的作用，为开发新型糖尿病治疗药物指明方向。
关键词：胰高血糖素样肽1；胰岛素；糖尿病；信号传导
Abstract: Abstract: Glucagon-like peptide-1 is a peptide hormone that controls insulin secretion and glucose metabolism. Following binding with its receptor, mainly through cAMP and PI3K signal pathways, GLP-1 stimulates glucose-dependant insulin secretion, b-cell proliferation and enhances the differentiation of new b-cells from progenitor cells. Studies on GLP-1R structure and signal transduction pathways would further our understanding on its role in the pathogenesis of type 2 diabetes mellitus, thereby developing new therapeutic strategies for diabetes.
Key words: glucagon-like peptide-1; insulin; diabetes; signal transduction
