《生命科学》 2025, 37(6): 724-734

N6-甲基腺苷RNA甲基化修饰在肝纤维化中的研究新进展

陈培杰^1,2,* , 王　涵^1,2

¹安徽医科大学第一附属医院药学部，合肥 230012 ²安徽省公共卫生临床中心药学部，合肥 230012

摘　要：

N6- 甲基腺嘌呤(N6-methyladenosine, m6A) 是真核生物中最常见的RNA 甲基化修饰，在肝脏中含量较高。M6A 主要由甲基转移酶、去甲基化酶及甲基识别蛋白催化调节，可通过影响RNA 的转录、剪切、降解及翻译等过程发挥生物学功能，参与多种疾病进程。肝纤维化(hepatic fibrosis, HF) 是以肝内结缔组织增生和胶原沉积为主要特征的肝脏慢性病变，m6A 修饰可通过调节多种靶基因的表达影响肝纤维化。本主要综述m6A 修饰及其调节因子在肝纤维化中的表达变化和生物学功能，以期为肝纤维化研究提供参考。

通讯作者：陈培杰 , Email:peijiechen@163.com

New advances of N6-methyladenosine RNA methylation modifications in hepatic fibrosis

CHEN Pei-Jie^1,2,* , WANG Han^1,2

¹Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230012, China ²Department of Pharmacy, Anhui Public Health Clinical Center, Hefei 230012, China

Abstract:

N6-methyladenosine (m6A) is the most common and abundant RNA methylation modification in eukaryotic cells, with a high content in liver tissue. m6A is mainly regulated by methyltransferases, demethylases and methyl recognition proteins. It plays significant roles in various diseases by influencing RNA transcription, splicing, degradation and translation. Hepatic fibrosis (HF) is a chronic liver disease characterized by connective tissue hyperplasia and collagen deposition in liver. m6A can be involved in liver fibrosis by regulating the expression of target genes. In this review, we focus on the expression and functions of m6A and its regulatory factors in the context of liver fibrosis. Our review aims to provide valuable references and insights for future studies of HF.

Communication Author：CHEN Pei-Jie , Email:peijiechen@163.com