《生命科学》 2025, 37(6): 693-703

GPNMB在骨重塑和疾病中的信号转导

杨绵绵¹ , 黄睿奇¹ , 温瑞明¹ , 杨　晶¹ , 衣雪洁^1,2,*

¹沈阳体育学院运动健康学院，沈阳 110102 ²沈阳体育学院体育社会科学研究中心，沈阳 110102

摘　要：

GPNMB (glycoprotein non-metastatic melanoma protein B) 是一种跨膜糖蛋白，广泛表达于多种细胞类型中，具有调节免疫反应、促进细胞增殖和迁移等多种生物学功能。GPNMB 在维持骨代谢平衡和调控骨重塑过程中同样发挥关键作用。本文深入探讨了GPNMB 在骨生理和病理过程中的最新研究进展，包括GPNMB 在维持骨量和骨质结构完整性中发挥的双重调节作用以及影响骨代谢的多条经典和新兴信号通路。另外，它在骨质疏松症、骨关节炎、骨肿瘤等骨病理过程中异常表达，参与疾病发生发展。GPNMB 作为一种新型骨代谢关键调节因子的发现，为揭示骨量维持的分子基础提供了新线索，并在骨质疏松症等骨病的病因研究和靶向治疗方面具有重要的理论价值和潜在的临床转化应用前景。

通讯作者：衣雪洁 , Email:yixuejie8387@163.com

GPNMB signaling in bone remodeling and disease

YANG Mian-Mian¹ , HUANG Rui-Qi¹ , WEN Rui-Ming¹ , YANG Jing¹ , YI Xue-Jie^1,2,*

¹College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China ²Sports Social Science Research Center, Shenyang Sport University, Shenyang 110102, C

Abstract:

GPNMB (glycoprotein non-metastatic melanoma protein B) is a transmembrane glycoprotein widely expressed in many cell types, with various biological functions such as regulating immune responses and promoting cell proliferation and migration. GPNMB also plays a key role in maintaining bone metabolic homeostasis and regulating bone remodeling. This review provides an in-depth discussion of the latest research progress of GPNMB in bone physiology and pathology, including the dual regulatory roles in maintaining bone mass and bone structural integrity as well as multiple classical and emerging signaling pathways affecting bone metabolism. In addition, it appears to be abnormally expressed in bone pathological processes such as osteoporosis, osteoarthritis, and bone tumors, and participates in disease development. The discovery of GPNMB as a novel key regulator of bone metabolism provides new clues to unravel the molecular basis of the maintenance of bone mass, and it has important theoretical value and potential clinical translational applications in etiological research and targeted therapy of osteoporosis and other bone diseases.

Communication Author：YI Xue-Jie , Email:yixuejie8387@163.com