《生命科学》 2025, 37(4): 372-383
SUMO化修饰在骨骼肌疾病中的作用及机制研究进展
摘 要：
骨骼肌作为人体最大的代谢和分泌器官，不仅在维持机体运动、代谢平衡及内分泌功能中起着至关重要的作用，而且具有很强的再生能力。骨骼肌损伤和骨骼肌萎缩等疾病，严重影响患者的生活质量，甚至危及生命。近年来，随着分子生物学的快速发展，小泛素样修饰物(small ubiqutin-related modifier, SUMO) 在骨骼肌健康与疾病中的作用日益受到学界的重视。本文旨在全面综述SUMO 的不同亚型及其在体内发挥作用的复杂调控网络，并剖析SUMO 化修饰在骨骼肌损伤和萎缩等疾病的发生、发展乃至治疗过程中的关键作用及机制。本综述不仅增进了对这类小分子修饰物在骨骼肌疾病发生发展中重要性的认识，也为未来开发针对骨骼肌疾病的新型治疗策略提供新的思路。
通讯作者：朱 琳 , Email:11251@gzsport.edu.cn 刘晓光 , Email:liuxg@gzsport.edu.cn
Abstract:
Skeletal muscle is the largest metabolic and secretory organ with powerful regenerative capacity, which plays an important role in maintaining body movement, metabolic balance, and endocrine function. Skeletal muscle diseases, such as skeletal muscle injury and skeletal muscle atrophy, seriously affect patients' quality of life and even impair their lives. Recently, with the rapid development of molecular biology, small ubiquitin-like modifier (SUMO) gets highly regarded in skeletal muscle health and disease. The aim of this paper is to comprehensively review the different isoforms of SUMO and their complex regulatory networks in vivo, and to analyze the key roles and mechanisms of SUMOylation in the progression and treatment of skeletal muscle injury and atrophy. This review not only enhances the understanding of the importance of these small molecule modifiers in the occurrence and development of skeletal muscle diseases, but also provides new ideas for the development of novel therapeutic strategies for skeletal muscle diseases in the future.
Communication Author：ZHU Lin , Email:11251@gzsport.edu.cn LIU Xiao-Guang , Email:liuxg@gzsport.edu.cn
