《生命科学》 2025, 37(3): 287-295

竞争性内源RNA在结核病中的研究进展

杨金兰 , 曾赵军 , 汤立军^*

中南大学生命科学学院，生物化学与分子生物学系，长沙 410013

摘　要：

结核病是发病率及致死率较高的传染性疾病之一，由结核分枝杆菌感染引起。近年来发现竞争性内源RNA 在各种疾病中起着关键的调控作用。长链非编码RNA、环状RNA、假基因转录产物以及信使RNA 等通过竞争性地结合微小RNA 调控相关基因的表达并影响结核病的发生发展。本文以竞争性内源RNA 的生物学组成和功能、影响竞争性内源RNA 调控结核病发生发展的相关因素为基础，阐述了不同类型竞争性内源RNA 在结核病发生发展过程中可能的作用机制，并探讨了竞争性内源RNA 之间相互作用网络在结核病治疗和预后中的临床意义。

通讯作者：汤立军 , Email:tljxie@csu.edu.cn

Research progress of competitive endogenous RNA in tuberculosis

YANG Jin-Lan , ZENG Zhao-Jun , TANG Li-Jun^*

Department of Biochemistry and Molecular Biology, School of Life Science, Central South University, Changsha 410013, China

Abstract:

Tuberculosis (TB) is one of the infectious diseases with high morbidity and lethality, caused by
Mycobacterium tuberculosis infection. Competing endogenous RNAs have been found in recent years to play key regulatory roles in various diseases. Long non-coding RNAs, circular RNAs, pseudogene transcription products, and messenger RNAs competitively bind to miRNAs to regulate the expression of relevant genes and influence the development of tuberculosis. Based on the biological composition and function of competitive endogenous RNAs, and the factors affecting the regulation of tuberculosis by competitive endogenous RNAs, this review describes the possible mechanisms of different types of competitive endogenous RNAs in the development of tuberculosis and discusses clinical significance of the interaction network of competing endogenous RNAs in the treatment and prognosis of tuberculosis.

Communication Author：TANG Li-Jun , Email:tljxie@csu.edu.cn